Pharmacists Provide Additional Line of Defense for Detecting Knee Osteoarthritis


Source: Wiley

Media Release: August 28, 2012

Canadian researchers have determined that community-based pharmacists could provide an added resource in identifying knee osteoarthritis (OA). The study, published in Arthritis Care & Research, a journal of the American College of Rheumatology (ACR), represents the first evidence supporting a collaborative approach to managing knee OA. Findings suggest that involving pharmacists, physiotherapists, and primary care physicians in caring for OA patients improves the quality of care, along with patient function, pain, and quality of life.

OA is the most prevalent form of arthritis where a progressive loss of articular cartilage in the joints causes joint pain and could lead to functional disability. Nearly 27 million Americans over the age of 25 have some form of OA according to the Centers for Disease Control and Prevention (CDC). Joints that receive repetitive impact such as fingers, hips, and knees are most often affected by OA. Medical evidence estimates that knee OA occurs in 10% of men and 13% of women over the age of 59. Prior research projects a 50% increase in OA prevalence over the next 10 to 20 years, with aging and obesity reported as the leading contributors to this increase.

“Many cases of knee OA go undiagnosed and patients often do not receive timely care to relieve pain, improve function and prevent disability,” said lead author Dr. Carlo Marra, PharmD, PhD, a Director with the Collaboration for Outcomes Research and Evaluation (CORE) and Professor of Pharmaceutical Sciences at the University of British Columbia in Vancouver, Canada. “Our study investigates a multidisciplinary intervention that involves pharmacists in the identification and patient care for those with knee OA.”

For this randomized, controlled trial, the team engaged 14 pharmacies to provide intervention therapy and 18 pharmacies to offer usual care (control). At least two pharmacists at each location were asked to identify and enroll participants 50 years or older who experienced knee pain or stiffness on most days of the last month and fulfilled other criteria such as having a body mass index (BMI) greater than 25 kg/m2, not participating in a formal exercise program in the previous 6 months, and difficulty with activities due to knee pain. The 73 patients in the intervention arm received OA screening questionnaires, education, pain medication management, physical therapy exercises, and primary care physician (PCP) communication. There were 66 participants in the control group who were given an educational pamphlet.

Patients in the intervention arm had a significantly higher quality of OA care (as measured by a quality indicator pass rate) than those in the control group. At three months and six months, participants in the intervention arm saw significantly greater improvement in their overall pain and function scores compared to those receiving usual care. Dr. Marra concludes, “Our findings suggest that pharmacists can effectively initiate interventions that address the gaps in OA patient care. With the rise in OA, collaborative care presents a novel approach in prevent and treating those with knee OA.” 


This study is published in Arthritis Care & Research. Media wishing to receive a PDF of this article may contact sciencenewsroom@wiley.com.

Full citation: “Pharmacist Initiated Intervention Trial in Osteoarthritis (PhIT-OA): A Multidisciplinary Intervention for Knee Osteoarthritis.” Carlo A. Marra, Jolanda Cibere, Maja Grubisic, Kelly A. Grindrod, Louise Gastonguay, Jamie M Thomas, Patrick Embley, Lindsey Colley, Ross T. Tsuyuki, Karim M. Khan, and John M. Esdaile. Arthritis Care and Research; Published Online: August 28, 2012 (DOI: 10.1002/acr.21763).

URL Upon publication: http://doi.wiley.com/10.1002/acr.21763

Author Contact: To arrange an interview with Dr. Marra, please contact Jimi Galvão with the University of British Columbia in Vancouver at jimi.galvao@ubc.ca or at +1 604-827-3309.

About the Journal: Arthritis Care & Research is an official journal of the American College of Rheumatology (ACR), and the Association of Rheumatology Health Professionals (ARHP), a division of the College. Arthritis Care & Research is a peer-reviewed research publication that publishes both original research and review articles that promote excellence in the clinical practice of rheumatology. Relevant to the care of individuals with arthritis and related disorders, major topics are evidence-based practice studies, clinical problems, practice guidelines, health care economics, health care policy, educational, social, and public health issues, and future trends in rheumatology practice. The journal is published by Wiley-Blackwell on behalf of the American College of Rheumatology (ACR). For more information, please visit http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)2151-4658.

About Wiley: Founded in 1807, John Wiley & Sons, Inc. has been a valued source of information and understanding for more than 200 years, helping people around the world meet their needs and fulfill their aspirations. Wiley and its acquired companies have published the works of more than 450 Nobel laureates in all categories: Literature, Economics, Physiology or Medicine, Physics, Chemistry, and Peace.

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