The Faculty of Pharmaceutical Sciences

Research Interests:

analytical method development
drug receptor interactions
drug discovery
drug metabolism, drug interactions
quantitative structure-activity-relationships
toxicological investigations of drugs and metabolites

Dr. Frank S. Abbott

Title: Professor and Dean Emeritus

Email: fabbott@interchange.ubc.ca

Telephone: 604-822-2566

Fax: 604-822-3035

Links: http://afpc.info/about/council.php

Degrees:

1959	B.S.P.	Pharmacy (with Great Distinction)	University of Saskatchewan
1962	M.Sc.	Medicinal Chemistry	University of Saskatchewan
1966	Ph.D.	Medicinal Chemistry	Purdue University

Research Focus:

Current research focus is on reactive metabolites and the production of reactive oxygen species as mechanisms of idiosyncratic drug toxicity. This information is used in drug discovery to produce safer drugs.

Current Projects:

CIHR: - Valproic acid analogues: glutathione dependant metabolism and mechanisms of toxicity.

*CIHR Proof of Principle Grant: CNS-active valproate analogues with improved safety profiles.>

Selected Publications:

Stoyan Karagiozov and Frank S. Abbott, "Practical Stereoselective Synthesis of (2E)- and (2Z)-4-Cycloalkyidenebut-2-enoic acids", Synthetic Communications, 34, 871-888 (2004).

Vincent Tong, Xiao Wei Teng, Thomas K H Chang, and Frank S Abbott, "Valproic Acid I: Time course of lipid peroxidation biomarkers, liver toxicity, and valproic acid metabolites in rats", Toxicological Sciences, 86, 427-435 (2005).

Vincent Tong, Xiao Wei Teng, Thomas K H Chang, and Frank S Abbott, "Valproic acid II: Effects on oxidative stress, mitochondrial membrane potential and cytotoxicity in glutathione-depleted rat hepatocytes", Toxicological Sciences, 86, 436-443 (2005).

Aspasia Michoulas, Vincent Tong, Xiao Wei Teng, Thomas Chang, Frank Abbott and Kevin Farrell, "Oxidative stress in children receiving valproic acid", J Pediatr, 149, 692-696 (2006).

Tony Kiang, Ping Ho, Reza Anari, Vincent Tong, Frank Abbott, and Thomas Chang, "Contribution of CYP2C9, CYP2A6, and CYP2B6 to valproic acid metabolism in hepatic microsomes from individuals with the CYP2C9*1/*1 genotype", Toxicological Sciences, 94, 261-271 (2006).

Andrew Numa, Frank Abbott, and Thomas Chang, "Effect of Ginkgo Biloba extract on oxidative metabolism of valproic acid in hepatic mictosomes from donors with the CYP2C9 *1/*1 genotype", Can J Physiol Pharmacol 85, 848-855 (2007).