Leon Wan

About the Students

E-mail: leonwan@interchange.ubc.ca


Degree: M.S. in Biochemistry
Institution: California State University
Year: 2008
Degree: B.S. in Molecular Biology and Biochemistry
Institution: Simon Fraser University
Year: 2004

Current Position

Position: Ph.D. Student
Supervisor: Dr. H.M. Burt

Scholarships + Awards

Name: Graduate Dean’s List
Organization: California State University, Long Beach
Year: 2008
Name: Boeing Scholarship
Organization: California State University, Long Beach
Year: 2008
Name: Dr. Louise Perlgut Scholarship in Biochemistry for outstanding student
Organization: California State University, Long Beach
Year: 2005

About The Research

Inhibition of Drug Efflux Transport Proteins by Amphiphilic Diblock Copolymers P-glycoprotein (Pgp), a transmembrane drug efflux transporter, is highly expressed in intestinal and blood brain barrier tissues and in multi-drug resistant (MDR) cancer cell lines, leading to a decrease in cellular drug absorption. Our preliminary study has indicated that a series of low molecular weight amphiphilic diblock copolymers based on methoxy poly (ethylene glycol) and poly (caprolactone), MePEG-b-PCL is capable of inhibiting Pgp function leading to increased cellular retention and therapeutic activity of drugs that are substrates of Pgp. The goal of the research is to design a diblock copolymer nanoparticulate delivery system that can modulate Pgp function leading to improved anticancer drug uptake and enhanced efficacy against MDR tumors.

Publications + Presentations

  • Beckstead, J.A., Wong, K., Guta V., Wan, C.P., Cook, V.R., Weinberg, R.B., Weers, P.M., Ryan, R.O. 2007. "The C-terminus of apolipoprotein A-V modulates lipid binding activity" J. Biol. Chem. May 25;282(21):15484-9.
  • Leon, L.J., Idangodage, H., Wan, C.P., and Weers, P.M. 2006. "Apolipophorin III: lipopolysaccharide binding requires helix bundle opening" Biochem. Biophys. Res. Commun. Oct 6;348(4):1328-33.


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