Marc Levine


About the Principal Investigator

Marc Levine
E-mail: levine@interchange.ubc.ca
Phone: 604-822-5027
Fax: 604-822-3035

Training

Degree: B.Sc. (Honours), Genetics
Institution: McGill University
Year: 1970
Degree: B.Sc., Pharmacy
Institution: University of British Columbia
Year: 1978
Degree: Ph.D.
Institution: Biology
Year: McMaster University

Current Position

Position: Professor

Links

Research Interests:

  • clinical and population pharmacokinetics
  • drug metabolism and pharmacogenetics
  • therapeutic drug monitoring
  • clinical trials
  • pharmaceutical outcomes research

Research Focus

Our studies involving clinical pharmacokinetics and drug metabolism are aimed at understanding the effects of drug interactions and genetic polymorphisms on drug therapy. Use of population pharmacokinetic data and Bayesian methods to optimize dosing are also investigated. Our clinical research involves both observational studies and clinical trials to evaluate outcomes of drug therapy. Studies using large health databases are employed to address population-based questions of effectiveness and safety of drug therapy.

Current Projects

Bayesian forecasting and vancomycin monitoring in premature neonates

We are using population pharmacokinetic data to optimize vancomycin monitoring in these patients.

Pharmacogenetics of codeine metabolism to morphine in Asian and Caucasian pediatric patients

We are developing genotyping methods for cytochrome P450 2D6*10 in Asian patients and investigating the effect of this allele on morphine production.

Population-based comparison of two regimens for emergency contraception

Using population and clinical data from over 13,000 cases, we plan to compare the effectiveness of levonorgestrel and a combination of ethinyl estradiol and norgestrel when used for emergency contraception.

Selected Publications

  • Wrishko RE, Levine M, Koo D, Abbott P, Hamilton D. Vancomycin Pharmacokinetics and Bayesian estimation in pediatric patients. Ther. Drug Monit. 22: 522-531, 2000.
  • Soon JA, Levine M. Screening for Depression among patients in long-term care facilities: a randomized, controlled trial of physician response. J. Am. Geriatr. Soc. 50: 1092-99, 2002.
  • Madeira ML, Levine M, Chang TKH, Mirfazaelian A, Bellward GD. The effect of cimetidine on dextromethorphan O-demethylase activity of human liver microsomes and recombinant CYP2D6. Drug. Metab. Dispos. 32: 460-467, 2004.
  • Soon JA, Levine M, Osmond BL, Ensom MHH, Fielding DW. Expanding Access to Emergency Contraceptives in British Columbia. (Submitted for publication)

 

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