Mary Ensom
About the Principal Investigator
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Training
| Degree: | B.S. Pharmacy |
| Institution: | University of Kentucky |
| Period: | 1977 |
| Degree: | Pharm. D. |
| Institution: | University of Kentucky |
| Period: | 1985 |
| Degree: | Fellowship in Clinical Pharmacokinetics |
| Institution: | University of Kentucky |
| Period: | 1985 - 1987 |
Previous Positions
| Position: | Satellite Unit/Decentralized Pharmacist |
| Institution: | Medical University of South Carolina Hospital, Charleston, SC |
| Period: | 1978 - 1980 |
| Position: | Clinical Instructor, part-time |
| Institution: | Medical University of South Carolina Hospital, Charleston, SC |
| Period: | 1979 - 1980 |
| Position: | Preceptor |
| Institution: | Medical University of South Carolina Hospital, Charleston, SC |
| Period: | 1979 - 1980 |
| Position: | Pharmacist |
| Institution: | Virginia Mason Hospital, Seattle, WA |
| Period: | 1980 - 1982 |
| Position: | Preceptor |
| Institution: | Virginia Mason Hospital, Seattle, WA |
| Period: | 1981 - 1982 |
| Position: | Pharmacist |
| Institution: | Central Baptist Hospital, Lexington, KY |
| Period: | 1982 - 1985 |
| Position: | Director, Clinical Pharmacokinetics Service |
| Institution: | University of Kentucky, Lexington, KY |
| Period: | 1987 - 1997 |
| Position: | Assistant Professor, Division of Pharmacy Practice and Science, College of Pharmacy (full-time) |
| Institution: | University of Kentucky, Lexington, KY |
| Period: | 1987 - 1992 |
| Position: | Assistant Professor, Department of Pathology, College of Medicine (joint appointment) |
| Institution: | University of Kentucky, Lexington, KY |
| Period: | 1991 - 1992 |
| Position: | Associate Professor, Division of Pharmacy Practice and Science, College of Pharmacy (full-time) |
| Institution: | University of Kentucky, Lexington, KY |
| Period: | 1992 - 1997 |
| Position: | Associate Professor, Department of Pathology, College of Medicine (joint appointment) |
| Institution: | University of Kentucky, Lexington, KY |
| Period: | 1992 - 1997 |
| Position: | Adjunct Faculty, Division of Pharmacology and Experimental Therapeutics, College of Pharmacy (full-time) |
| Institution: | University of Kentucky, Lexington, KY |
| Period: | 1996 - 1997 |
| Position: | Voluntary Faculty, Division of Pharmacy Practice and Science, College of Pharmacy |
| Institution: | University of Kentucky, Lexington, KY |
| Period: | 1997 - present |
| Position: | Associate Professor, Division of Clinical Pharmacy |
| Institution: | University of British Columbia |
| Period: | 1997 - 2000 |
Current Position
| Position: | Clinical Pharmacy Specialist, Children’s and Women’s Health Centre of British Columbia (cross-appointment) |
| Institution: | University of British Columbia |
| Position: | Research Associate, Pharmacy Department, St. Paul’s Hospital |
| Institution: | University of British Columbia |
| Position: | Professor, Division of Clinical Pharmacy |
| Institution: | University of British Columbia |
| Position: | Director, Doctor of Pharmacy Program |
| Institution: | University of British Columbia |
| Position: | Distinguished University Scholar |
| Institution: | University of British Columbia |
| Position: | Senior Associate Clinician Scientist |
| Institution: | Child & Family Research Institute |
| Position: | Member, Division of Drug Evaluation |
| Institution: | Centre for Drug Research and Development (CDRD) |
Major Awards
| Name: | Upjohn Innovative Clinical Practice Research Award |
| Organization: | American College of Clinical Pharmacy |
| Period: | 1988 |
| Name: | Astra Clinical Pharmacy Research Award |
| Period: | 1990 |
| Name: | Clinical Faculty of the Year |
| Organization: | American College of Pharmacy |
| Period: | 1991 |
| Name: | Fellow, American Society of Health-System Pharmacists, FASHP |
| Period: | 1994 |
| Name: | Fellow, American College of Clinical Pharmacy, FCCP |
| Period: | 1994 |
| Name: | Rhone-Poulenc Rorer Pulmonary Research Award< |
| Organization: | American College of Pharmacy |
| Period: | 1994 |
| Name: | Pharm.D. Class Outstanding Teacher Award |
| Organization: | University of Kentucky |
| Period: | 1995 |
| Name: | Pharm.D. Class Outstanding Teacher Award |
| Organization: | University of Kentucky |
| Period: | 1996 |
| Name: | Outstanding Third Year Professor Award |
| Organization: | University of Kentucky |
| Period: | 1997 |
| Name: | Maria Machado Award |
| Organization: | B.C. Branch C.S.H.P. |
| Period: | 1998 |
| Name: | Publication Award |
| Organization: | B.C. Branch C.S.H.P. |
| Period: | 1998 |
| Name: | Pfizer Pharmacy Practice Award |
| Organization: | B.C. Branch C.S.H.P. |
| Period: | 2000 |
| Name: | Killam Teaching Prize |
| Organization: | UBC |
| Period: | 2000 |
| Name: | Bristol-Myers Squibb Excellence in Teaching Award |
| Organization: | UBC |
| Period: | 2001 |
| Name: | Fellow, Canadian Society of Hospital Pharmacists, FCSHP |
| Period: | 2003 |
| Name: | Best Poster Award (1st place) |
| Organization: | Canadian College of Clinical Pharmacy Annual General Meeting |
| Period: | 2003 |
| Name: | Best Poster Award (1st place) |
| Organization: | American College of Clinical Pharmacy Annual Meeting |
| Period: | 2003 |
| Name: | Distinguished University Scholar |
| Organization: | UBC |
| Period: | 2003 |
| Name: | Publication Award |
| Organization: | B.C. Branch C.S.H.P. |
| Period: | 2005 |
| Name: | ACCP Russell R Miller Publication Award, “in recognition of sustained and outstanding contributions to the literature of clinical pharmacy, thereby advancing both clinical pharmacy practice and rational pharmacotherapy” |
| Period: | 2006 |
| Name: | Publication Award |
| Organization: | B.C. Branch C.S.H.P. |
| Period: | 2006 |
| Name: | Fellow, Canadian Academy of Health Sciences, FCAHS |
| Period: | 2007 |
| Name: | Publication Award, |
| Organization: | B.C. Branch C.S.H.P. |
| Period: | 2007 |
| Name: | Killam Research Prize (in Science Category) |
| Organization: | UBC |
| Period: | 2007 |
| Name: | Publication Award |
| Organization: | B.C. Branch C.S.H.P. |
| Period: | 2008 |
| Name: | Specialties in Pharmacy Practice Award |
| Organization: | C.S.H.P. |
| Period: | 2009 |
| Name: | Class of 2009 Master Teacher Award |
| Organization: | UBC |
| Period: | 2009 |
Links
About the Lab and Group
What distinguishes my translational (bedside to bench to bedside) research program from most others’ in the Faculty is that it is both clinical and laboratory-based. My long-term research focus has been in clinical pharmacokinetics and pharmacodynamics (particularly as these disciplines relate to: women's health; effects of gender, age, and other pathophysiologic states on pharmacokinetics and pharmacodynamics; and novel approaches to therapeutic drug monitoring), with more recent interests in pharmacogenetics and pharmaceutical outcomes evaluations.
Every day, I use my clinical practice experiences to identify relevant pharmacokinetic/pharmacodynamic/pharmacogenetic problems that are then studied in the laboratory. As such, our research team (specific for each project) consists of clinicians and laboratory scientists and a full array of trainees (BSc, MSc, PharmD, and PhD students; pharmacy residents; and postdoctoral fellows).
As an integrator who bridges the gap between the basic and clinical sciences, the goal of my translational research program is to address clinical problems from a qualitative, quantitative, and mechanistic perspective and to make a difference in the health and well-being of patients (i.e., study results are directly and immediately incorporated into patient care).
Training Environment
“Your profession is not what brings home your paycheck. Your profession is what you were put on earth to do with such passion and such intensity that it becomes spiritual in calling.” ~ Vincent Van Gogh
“It is the preceptor who sets the tone of the training program. He accomplishes this by what he does personally, by what he stands for, by the contributions he makes to his profession, by his actions and by his sense of values. The religious precept that one must lose himself to find himself is certainly true of the preceptor. The life of a dedicated preceptor is the endless pursuit of goals, many of which are unattainable.” ~ Donald E Francke
Projects
Immunosuppressant Pharmacokinetics, Limited Sampling Strategies, and Pharmacogenetics
These projects characterize the pharmacokinetics of (and develop limited sampling strategies for) mycophenolate and tacrolimus in lung, heart, kidney, and islet transplant recipients and ascertain the contribution of genetic polymorphisms (e.g., UGT and ABCC2) and other factors to inter-patient variability in pharmacokinetics of mycophenolate and its glucuronidated metabolites.
Impact of Various Pathophysiologic Conditions on Pharmacokinetics and Pharmacodynamics
These projects evaluate the pharmacokinetics and pharmacodynamics of various drugs in patients with various pathophysiologic conditions [e.g., intravenous immunoglobulin (IVIG) in patients with recurrent pregnancy loss (prior to and during pregnancy) and in patients with other immunologic conditions, etc.].
Stability of Medications in Extemporaneously Prepared Formulations for Use in Pediatric Patients
These projects evaluate the stability of various extemporaneously-compounded oral and intravenous formulations and apply the results immediately to care of pediatric patients
Various Other Pharmacokinetics, Pharmacodynamics, Pharmacogenetics, and Pharmaceutical Outcomes Studies as Co-Investigator.
Selected Publications
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